Effect of Acid and Base on Losartan by Uv Spectroscopy

Chemically Losartan is {2-N-butyl-4-chloro-5-hydroxymethyl-1-[(2′(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]imidazole}. it is a typical angiotensin II (Ang II) type I receptor (AT1R) blocker that has been used for regulation of blood pressure and fluid homeostasis. Forced degradation studies are used to identify reactions which may occur to degrade a processed product. Usually conducted before final formulation, forced degradation uses external stresses to rapidly screen material stabilities. The forced degradation studies on drug substance involves photo Acid/base Stress testing, photo degradation, Temperature and or with humidity, Time, pH variation (low and high).In our recent research we study degradation parameters on losartan 50mg tablets. When Losartan subjected to 0.1 N HCl and 0.1N NaOH, Losartan showed decreased availability i.e. 99.59% in the presence of acid while it showed slight changes in terms of availability i.e. 99.91% in the presence of base. it shows decreased availability i.e. 99.75% in case of UV light of 246nm.